The Molecular Virology Research Group is based at the Unviersity of Liverpool and is led by Prof. James Stewart. The focus of research is on the use of molecular techniques to study the pathogenesis of and host response to virus infections of man and animals.
Most of my group's current research programme is centred on the use of influenza A virus, respiratory syncytial virus and murine γ-herpesvirus-68 (MHV-68) to study pathogenesis, immunology and virus-host interactions in the respiratory tract. These studies use virus reverse genetics combined with transgenic mouse technology, molecular pathology, transcriptomics and proteomics to dissect pathogenic mechanisms.
In additiion, there are projects working on the pathogenesis of ovine herpesvirus 2 (OvHV-2) in malignant catarrhal fever of domestic cattle and the role of equine herpesvirus 5 in equine multinodular pulmonary fibrosis.
A major current project is the role of BPIF/PLUNC proteins in the host defence against respiratory virus infection. BPIF proteins are secreted into the respiratory tract and are currently of undefined function. We have generated preliminary data showing differential expression of BPIF proteins after infection. We are currently investigating the importance of on of the these molecules, BPIFA1, in the innate defence against viruses in the lung using knockout mice in collaboration with Colin Bingle (Sheffield) and Ralph Tripp (University of Georgia Athens) as part of a current BBSRC project grant.
Further information on projects, group members and additional online resources can be found by browsing the relevant pages on this site